Should You Use Kinerase as an Anti-Aging Skin Treatment?

An anti-aging cream that’s received a great deal of attention in the last few years is Kinerase. Kinerase is a topical agent applied topically to the skin that’s being touted for its ability to reduce the visible signs of skin aging. It’s available without a prescription and is currently being marketed as a wrinkle reduction cream through physician offices, medical spas, and online. It’s claimed that kinerase gives similar skin anti-aging effects to the prescription retinoids without the side effects frequently seen with retinoids such as skin redness and peeling. Does kinerase really live up to the marketing claims?

What exactly is Kinerase and what gives it the ability to function as an anti-aging cream? The active ingredient in kinerase is a plant component known as kinetin. Kinetin is a plant derived component that functions in the plant as a growth hormone like substance to help retard aging of the plant. Because kinetin has shown the ability to slow down plant aging, it’s thought to have some anti-aging properties when applied topically to human skin. Kinetin has also been shown to have antioxidant properties which may help to reduce the effects of free radicals on human skin cells. Another important property of kinectin is that it’s been shown to aid in repair of DNA , the genetic material found in every cell in the body, including skin cells.

A study carried out at the University of California in Irvine looked at different strengths of Kinerase and their effects on human skin over a 48 week period. The groups receiving the Kinerase showed significant improvement in the texture of the skin, the appearance of fine wrinkles, and hyperpigmentation. Although the results of this study show support for the topical anti-aging effects of Kinerase, double blind, placebo-controlled studies are still absent and it may be premature to say that Kinerase is as effective as the well studied, time tested topical retinoids.

Although Kinerase needs further study in order to be recommended as an alternative to prescription strength retinoid preparations, patient reviews of this product have been favorable. The preponderance of patients using Kinerase as an anti-aging cream report improvement in skin roughness, uneven skin pigmentation, and improvement in the appearance of fine wrinkles. Plus, its antioxidant effects and its ability to repair DNA make it likely that it would have some anti-aging benefits for aging skin.

Should you consider using Kinerase as an anti-aging skin treatment? If you make this choice, it won’t come cheaply. A half ounce of Kinerase based cream can cost over a hundred dollars. If you are unable to tolerate use of prescription strength retinoids due to skin irritation and redness, Kinerase may be a reasonable alternative. If you’re currently on prescription strength retinoids and are tolerating them well, Kinerase may not offer any additional advantages for you and it may be best to wait until studies comparing the effectiveness of retinoids versus Kinerase are completed before jumping on the Kinerase bandwagon.

Is Retinol Really Effective for Skin Rejuvenation?

With so much hype and misinformation associated with the marketing of anti-aging skin care products, it can be difficult to determine what actually works for improving the texture and appearance of aging skin. One skin care ingredient that’s been promoted heavily for skin rejuvenation is retinol. Is there truth behind the widely claimed benefits of usin retinol for skin rejuvenation?

Retinol is a purified form of vitamin A which is thought to stimulate collagen product when applied directly to the skin. It does this by stimulating skin fibroblasts, the cells that produce collagen, and by inhibiting the action of enzymes that promote breakdown of the skin’s collagen support structure.

The limiting factor with many skin care products that advertise that they promote collagen production is that the molecules are unable to penetrate deeply enough to gain access to the dermis where the fibroblasts are located. Hence, they’re unable to stimulate collagen synthesis despite their advertising claims. This where the retinol molecule is different. It has the ability to penetrate the outer layer of the skin, the epidermis, and gain access to the inner dermis where it can stimulate the fibroblasts to produce more collagen.

The ability to gain access to the dermis and stimulate collagen production gives retinol the ability to improve the appearance of lines and wrinkles as well as counteract some of the skin damage created by years of sun exposure. Retinol also increases the thickness of the outer skin layer, the epidermis. This results in a skin with a finer, more translucent texture as well as a reduction in skin roughness.

Do studies confirm that retinol works to improve the appearance of aging skin? A study performed on 31 subjects to test the effects of retinol on skin texture and appearance. The individuals had a 0.4% retinol solution applied to one arm and a placebo to the other. Not only did the arm that received the retinol show improvement in skin roughness and texture, but a skin biopsy revealed an increase in the precursors of collagen synthesis, suggesting that collagen production was being stimulated. In addition, retinol has been used by dermatologists and physicians for many years as an anti-aging cream with good results.

It appears that retinol is effective both in improving the texture of the skin as well as reducing the appearance of fine lines. By stimulating collagen production, it may also compensate for some of the solar damage accrued over the years. Although you can buy dilute retinol formulations over the counter, they may not have the same benefit as prescription formulations available from your doctor. Because prescription strict retinol in the form of Retin-A and its derivatives may be too irritating for some people’s skin, it may be prudent to start with a lower strength, non-prescription formulation and advance to the prescription form if results aren’t achieved. Remember to always wear a sunblock when using retinol since it increases sensitivity to the sun.

Here’s a Side Effect to Hope for: Longevity

In most clinical trials, scientists and doctors hope for the fewest number of side effects possible, but in a new batch of anti-aging research, doctors are hoping that there is a significant side effect to their trials: longer life.

Mice kept in a germ-free room with intensive nursing care at Harvard Medical School are hopefully the key to this side effect. A mouse gym holds a miniature exercise machine that tests the rodents’ ability to balance on a bar, while in a nearby water maze, mice must recall visual cues from their “training” to swim to safety on a hidden platform - thereby testing memory powers. (Don’t worry: the that forget their lessons are rescued as they start to submerge.)

The new drugs being tested are called Sirtuin activators, and are based on a theory that most species have an ancient strategy for riding out famines: switch resources from reproduction to tissue maintenance. These activators appear to be triggered in mice when fed a healthy diet with 30 % fewer calories. The mice seem to live longer because they are somehow protected from the usual diseases that kill them.

Left to our own devices, many of us couldn’t stick to a diet that requires a 30% cut in calories, so a drug that could initiate this “famine” reflex is what the study is working toward. Safety tests in people have just started, with no adverse effects so far.

The hope is that activating sirtuins in people would, like a calorically restricted diet in mice, avert degenerative diseases so often linked to aging - things like diabetes, heart disease, cancer and Alzheimer’s. Because the FDA doesn’t have a specific approval category for longevity drugs, if the drug resulting from this study is submitted for approval, it needs to be for a specific disease.

Read more at my Anti-Aging blog.

6 Ways to Prevent Crow’s Feet

One of the first signs of skin aging experienced by many people is the appearance of tiny lines and creases at the corners of the eyelids commonly known as crow’s feet. These lines initially may not be noticeable until the person smiles or moves their face. Although they may be experienced only with movement at first, over time these creases deepen and become a permanent part of the facial architecture. The good news about crow’s feet is they can be prevented to some degree with proper anti-aging skin care habits. Here’s how to prevent crow’s feet from developing or worsening:

Wear sunscreen on a daily basis.

You probably already know what an important role the sun plays in promoting skin aging. This is particularly true for the delicate skin tissue around the eyes. One of the best ways to prevent crow’s feet is to invest in a good sunblock that filters out both UVA and UVB rays. It should have an SPF of at least fifteen to give optimal anti-aging protection. To be effective, it needs to be applied in sufficient amounts and worn consistently when you’re out in the sun.

Get a good pair of sunglasses.

When you spend time in the bright sun without sunglasses, you’ll squint without being aware of it. Repetitive squinting is a major factor in promoting formation of crow’s feet. Repetitive movements due to squinting eventually take their toll on the delicate tissue surrounding the eyes particularly when collagen production starts to dwindle with age. Buy a good pair of sunglasses and wear them every time you go out into bright sunlight. Be sure they have a good UV filter to prevent damage to your retina. Make them a standard part of your anti-aging strategy.

Take breaks from your computer monitor.

People rarely think of their computer monitor as contributing to skin aging and crow’s feet. If you stare at a bright monitor all day, your eyes will eventually fatigue and you’ll start to squint. The result is premature formation of undereye wrinkles and crow’s feet. If you work in front of a computer monitor all day, give your eyes frequent breaks.

Ditch the smokes.

Smoking is a major cause of premature skin aging as well as crow’s feet. The smoke from a burning cigarette creates eye irritation which encourages squinting. Plus, smoking reduces oxygenation of the skin tissue as well as vitamin C levels which can impact collagen synthesis. If you observe a smoker, they almost always have evidence of crow’s feet if they’re over the age of thirty. Kick the habit for your lungs as well as your skin.

Anti-aging eye care products can help.

Keep the area around the eyes moisturized with a product that contains vitamin C or glycolic acid. Vitamin C and glycolic acid are both thought to be anti-aging and appear to play a role in boosting collagen synthesis which helps to ward off crow’s feet. Another product proven to prevent fine lines, wrinkles, and crow’s feet is Retin-A. This anti-aging product is available by prescription from your doctor.

Another option

If you’re still not satisfied with the appearance of crow’s feet, you can have the area injected with Botox. This will immobilize the muscles which prevents squinting and can significant reduce the appearance of crow’s feet. These injections are usually done in a dermatologist’s or plastic surgeon’s office and can give instant improvement in the appearance of crow’s feet.

Don’t let crow’s feet ruin your appearance. Incorporate crow’s feet preventative measures into your anti-aging lifestyle and you’ll be rewarded with younger looking skin.

How to Prevent Loss of Muscle Mass With Aging

One of the consequences of aging is the shrinkage and loss of muscle tissue. This can have a variety of negative health consequences including a decrease in strength and mobility, loss of muscle tone, as well as weight gain secondary to the drop in metabolism related to the loss of muscle mass. Fortunately, there are simple steps you can take to help preserve muscle tissue as you age. Here are some anti-aging tips for preventing age related loss of muscle:

Start a resistance training program.

This is the most important anti-aging step you can take to preserve muscle mass. The reality is that without a resistance training program, you’ll lose muscle mass at a rate of around three percent every decade after the age of fifty. Resistance training can help to prevent critical loss of muscle tissue as well as build strength and increase mobility. Resistance training doesn’t necessarily have to involve weight lifting. You can use your own body resistance to build muscle by doing push-ups and sit-ups as well as by using resistance training aids such as weighted balls and resistance bands. If you’ve never taken part in a resistance training program before, schedule a session with a personal trainer to help formulate a plan for you. It’ll be well worth the investment.

Increase your protein intake.

Many older Americans fall short when it comes to protein consumption. If you’re unsure as to whether you’re getting enough protein in your diet to preserve muscle mass, use this simple formula. Convert your weight to kilograms by multiplying by 0.45. This will tell you how many grams of protein you should be consuming each day. (one gram per kilogram of body weight). Even if you don’t enjoy eating meat, you can still use vegetarian protein sources such as tofu and tempeh to get your daily protein quota.

Watch you vitamin D intake.

More attention has been focused on vitamin D recently and the anti-aging benefits it provides. Not only are studies showing it may prevent some of the chronic disease processes associated with aging, it also may help to preserve bone and muscle tissue. Since most foods are not good sources of vitamin D with the exception of fatty fish and fortified eggs, try to get ten minutes of direct sunlight on most days which should provide you with your daily vitamin D quota. Some experts are now recommending that a vitamin D supplement be taken on a daily basis, particularly if you live in an area that doesn’t get a great deal of direct sunlight.

Get your potassium.

A recent study showed that potassium may have an anti-aging role in preventing loss of muscle mass. The recommended daily intake of potassium is 3,500 milligrams. This particular study published in the Journal of Clinical Nutrition showed that older people who consumed at least this amount were better able to preserve muscle tissue than those who didn’t. To increase your potassium intake, try adding more fresh fruits and vegetables to your diet. Oranges and bananas are particularly good sources of potassium.

Loss of muscle mass is not an inevitable result of aging. Maintaining an active lifestyle, adding some resistance training, and altering your diet can help you maintain your muscle mass even into an advanced age. Why not give these muscle preserving, anti-aging strategies a try?

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